[Transversal study for the quantification of osteoporosis risk in an urban population]. / Studiu transversal pentru cuantificarea riscului de osteoporoza la o populatie din mediul urban.

UNLABELLED: Multifactorial disease, osteoporosis manifests as a "silent epidemics" characterized by the aggregation of the risk factors, the distribution of which has regional peculiarities. AIM: To determine the demographic, anthropometric, and life style-related factors in relation with T score obtained by measurement of bone mineral density, and the quantification of the detected factors for a correct monitoring of the surveyed population. MATERIAL AND METHOD: The descriptive study was carried out in a series of 364 individuals who underwent outpatient osteodensitometry and were interviewed according to a questionnaire. The risk was quantified by giving a score for each item. Densitometry permitted the calculation of T score, bone mineral density index, and rigidity index. The gathered information was included in a database, then processed and interpreted by using specific tests. RESULTS: The female-male ratio was 29: 1. Mean age was 57.08 +/- 10.03 years and the median 56 years. In 83.6% of the subjects weight was over 60 kg, at a mean height of 1.61 +/- 0.07 m. The prevalence of alcohol, coffee or tobacco consumption was not high, but 69.7% of the subjects were eating a diet low in diary products. The quantification of the global risk revealed that in over half of the subjects under study the score was below the average or dangerous level for developing osteoporosis. T score value showed that over 50% of the subjects had osteopenia, 9.2% manifest osteoporosis, and 39.9% values that include a mineralization deficit. CONCLUSION: The risk for bone changes specific to osteoporosis was low in the urban population under study, a concordance between the reduced probability of osteoporosis resulting from the value of the global score and the results of osteodensitometry being noticed.

[Research on risk factors associated with osteoporosis, on two samples of patients investigated using ultrasonic osteo-densitometry]. / Studiul factorilor de risc asociati cu osteoporoza, pe doua esantioane de pacienti investigati prin metoda osteodensitometriei ultrasonice.

AIM: To detect risk factors associated with osteoporosis, on two samples of patients investigated using ultrasonic osteo-densitometry method (UOD). OBJECTIVES: To found out the relation between anthropometrical data, factors which describe lifestyle of personal pathologic antecedents and T score obtained after UOD, as well as their classification. MATERIAL AND METHODS: The epidemiological and imaging assessments were carried out on two samples of 364 persons from general population (the A sample), and 144 (the B sample), respectively. The registered variables were processed using adequate statistical tests. RESULTS: In the A sample, over 50% of patients had, after the T score, osteopenia, and 10% suffered from osteoporosis. Concerning the lifestyle, we highlighted: a low lactates consumption (69.7%), coffee (14.3%) and alcohol (0.8%) consumption; sedentary life (48.9%), tobacco smoking (2.2%). The risk quantification by score calculation put in evidence an average of 9.9 +/- 3.3 (for a minimum of 4 and a maximum of 20). In the B sample, the T score varied between 4.77 and 1.67. The assessment of relation between the T score and lifestyle permitted the classification in risk, protection and indifferent factors. Coffee consumption is a weak protection factor (OR = 0.84), and tobacco smoking increases osteoporosis risk 4.13 times. The risk is 3.7 for alcohol consumers, as well as for low lactate consumption (OR=2.87). Sedentary life cannot consider a risk factor, in our research. CONCLUSION: Calculation of a individual score that show the weight risk in persons with densitometric alterations represents a practical method in monitoring persons who can be exposed of some handicap after alterations of bone structures.

[The evolution of lumbar myalgia under the influence of the product Pelnicol administered in suppositories]. / Evolutia mialgiilor lombare secundare sub influenta produsului "Pelnicol" administrat în supozitoare.

After having done a wide study in vitro and in vivo reported in several publications, we applied the lyophylized extract "Pelnicol" under the form of suppositories, in 36 cases of secondary back diseases. The improvement with "Pelnicol" suppositories is observed, by mean, the 6th day of treatment. It can be seen that etiopathological factors are determining the diseases evolution, which has to be, in first rang, considered causally. It is realised with the "Pelnicol" suppositories.

[Chronic reactive inflammations in the etiopathogenesis of malignant hematologic proliferations]. / Inflamatile cronice reactive în etiopatogenia proliferarilor maligne hematologice.

The malignant proliferations are induced by a multitude of etiological factors and possible pathogenic mechanisms. Three new clinical cases and other four previously reported cases of haematological malignant proliferations occurring during the evolution of some chronic reactive inflammatory processes due to various forms of immune deficit are discussed. A review of the literature and of the opinions regarding the pathogenic mechanism responsible for the occurrence and growth of malignant proliferations, especially in the cases with inborn or acquired immunodeficiency, are also included. The authors' pathogenic hypothesis for the cases with various acquired immune deficits and with secondary infectious or allergic reactions is that altered immune responses made possible a lasting antigenic stimulation of certain cell clones of the reactive inflammatory process. By this excessive demand, and instability of the genes has occurred and during their rearrangement a mutation with the depression of an oncogene, responsible for malignant growth, has resulted.